Below you will find a list of articles published by our research group.

ADHD and other psychiatric disorders

Sonuga-Barke EJ, Brookes KJ, Buitelaar J, Anney R, Bitsakou P, Baeyens D, Buschgens C, Chen W, Christiansen H, Eisenberg J, Kuntsi J, Manor I, Meliá A, Mulligan A, Rommelse N, Müller UC, Uebel H, Banaschewski T, Ebstein R, Franke B, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Thompson M, Taylor E, Asherson P, Faraone SV. Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2007 Nov 19; [Epub ahead of print] Pubmed-link

Fliers E, Rommelse N, Vermeulen SH, Altink M, Buschgens CJ, Faraone SV, Sergeant JA, Franke B, Buitelaar JK. Motor coordination problems in children and adolescents with ADHD rated by parents and teachers: effects of age and gender. J Neural Transm. 2007 Nov 12; [Epub ahead of print] Pubmed-link

van der Zwaluw CS, van den Wildenberg E, Wiers RW, Franke B, Buitelaar J, Scholte RH, Engels RC. Polymorphisms in the micro-opioid receptor gene (OPRM1) and the implications for alcohol dependence in humans. Pharmacogenomics. 2007 Oct;8(10):1427-1436. Pubmed-link

Kooij JS, Boonstra AM, Vermeulen SH, Heister AG, Burger H, Buitelaar JK, Franke B. Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1). Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 22; [Epub ahead of print] Pubmed-link

Boonstra AM, Kooij JJ, Buitelaar JK, Oosterlaan J, Sergeant JA, Heister JG, Franke B. An exploratory study of the relationship between four candidate genes and neurocognitive performance in adult ADHD. Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 20; [Epub ahead of print] Pubmed-link

de Kovel CG, Franke B, Hol FA, Lebrec JJ, Maassen B, Brunner H, Padberg GW, Platko J, Pauls D. Confirmation of dyslexia susceptibility loci on chromosomes 1p and 2p, but not 6p in a Dutch sib-pair collection. Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 20; [Epub ahead of print] Pubmed-link

Neale BM, Sham PC, Purcell S, Banaschewski T, Buitelaar J, Franke B, Sonuga-Barke E, Ebstein R, Eisenberg J, Mulligan A, Gill M, Manor I, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Taylor E, Thompson M, Zhou K, Asherson P, Faraone SV. Population differences in the International Multi-Centre ADHD Gene Project. Genet Epidemiol. 2007 Sep 14; [Epub ahead of print] Pubmed-link

Lasky-Su J, Banaschewski T, Buitelaar J, Franke B, Brookes K, Sonuga-Barke E, Ebstein R, Eisenberg J, Gill M, Manor I, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Taylor E, Zhou K, Thompson M, Asherson P, Faraone SV. Partial replication of a DRD4 association in ADHD individuals using a statistically derived quantitative trait for ADHD in a family-based association test. Biol Psychiatry. 2007 Nov 1;62(9):985-90. Epub 2007 Jun 8. Pubmed-link

Brookes KJ, Neale B, Xu X, Thapar A, Gill M, Langley K, Hawi Z, Mill J, Taylor E, Franke B, Chen W, Ebstein R, Buitelaar J, Banaschewski T, Sonuga-Barke E, Eisenberg J, Manor I, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Faraone SV, Asherson P. Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth. Am J Med Genet B Neuropsychiatr Genet. 2007 May 24; [Epub ahead of print] Pubmed-link

Asherson P, Brookes K, Franke B, Chen W, Gill M, Ebstein RP, Buitelaar J, Banaschewski T, Sonuga-Barke E, Eisenberg J, Manor I, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Faraone SV. Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD. Am J Psychiatry. 2007 Apr;164(4):674-7. Pubmed-link

Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N, Anney R, Franke B, Gill M, Ebstein R, Buitelaar J, Sham P, Campbell D, Knight J, Andreou P, Altink M, Arnold R, Boer F, Buschgens C, Butler L, Christiansen H, Feldman L, Fleischman K, Fliers E, Howe-Forbes R, Goldfarb A, Heise A, Gabriëls I, Korn-Lubetzki I, Johansson L, Marco R, Medad S, Minderaa R, Mulas F, Müller U, Mulligan A, Rabin K, Rommelse N, Sethna V, Sorohan J, Uebel H, Psychogiou L, Weeks A, Barrett R, Craig I, Banaschewski T, Sonuga-Barke E, Eisenberg J, Kuntsi J, Manor I, McGuffin P, Miranda A, Oades RD, Plomin R, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Taylor E, Thompson M, Faraone SV, Asherson P. The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry. 2006 Oct;11(10):934-53. Epub 2006 Aug 8. Erratum in: Mol Psychiatry. 2006 Dec;11(12):1139. Aneey, R [corrected to Anney, R]. Pubmed-link

de Kovel CG, Hol FA, Heister JG, Willemen JJ, Sandkuijl LA, Franke B, Padberg GW. Genomewide scan identifies susceptibility locus for dyslexia on Xq27 in an extended Dutch family. J Med Genet. 2004 Sep;41(9):652-7. Pubmed-link

Pharmacogenomics

Zhernakova A, Alizadeh BZ, Bevova M, van Leeuwen MA, Coenen MJ, Franke B, Franke L, Posthumus MD, van Heel DA, van der Steege G, Radstake TR, Barrera P, Roep BO, Koeleman BP, Wijmenga C. Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases. Am J Hum Genet. 2007 Dec;81(6):1284-8. Pubmed-link

Alizadeh BZ, Valdigem G, Coenen MJ, Zhernakova A, Franke B, Monsuur A, van Riel PL, Barrera P, Radstake TR, Roep BO, Wijmenga C, Koeleman BP. Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis. Hum Mol Genet. 2007 Nov 1;16(21):2552-9. Pubmed-link

Coenen MJ, Toonen EJ, Scheffer H, Radstake TR, Barrera P, Franke B. Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis. Pharmacogenomics. 2007 Jul;8(7):761-773. Pubmed-link

Radstake TR, Fransen J, Toonen EJ, Coenen MJ, Eijsbouts AE, Donn R, van den Hoogen FH, van Riel PL. Macrophage migration inhibitory factor polymorphisms do not predict therapeutic response to glucocorticoids or to tumour necrosis factor alpha-neutralising treatments in rheumatoid arthritis. Ann Rheum Dis. 2007 Nov;66(11):1525-30. Epub 2007 Apr 24. Pubmed-link

Mulder H, Franke B, van der-Beek van der AA, Arends J, Wilmink FW, Scheffer H, Egberts AC. The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia. J Clin Psychopharmacol. 2007 Aug;27(4):338-43. Pubmed-link

Mulder H, Franke B, van der-Beek van der AA, Arends J, Wilmink FW, Egberts AC, Scheffer H. The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study. Pharmacogenomics J. 2007 Oct;7(5):318-24. Epub 2006 Oct 3. Pubmed-link

Kooij JS, Boonstra AM, Vermeulen SH, Heister AG, Burger H, Buitelaar JK, Franke B. Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1). Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 22; [Epub ahead of print] Pubmed-link

Riksen NP, Franke B, van den Broek P, Smits P, Rongen GA. The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. Pharmacogenet Genomics. 2007 Jul;17(7):551-4. Pubmed-link

Riksen NP, Franke B, Oyen WJ, Borm GF, van den Broek P, Boerman OC, Smits P, Rongen GA. Augmented hyperaemia and reduced tissue injury in response to ischaemia in subjects with the 34C > T variant of the AMPD1 gene. Eur Heart J. 2007 May;28(9):1085-91. Epub 2007 Mar 21. Pubmed-link

Radstake TR, Franke B, Wenink MH, Nabbe KC, Coenen MJ, Welsing P, Bonvini E, Koenig S, van den Berg WB, Barrera P, van Riel PL. The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis. Arthritis Rheum. 2006 Dec;54(12):3828-37. Pubmed-link

Mochtar CA, Laan W, Van Houwelingen KP, Franke B, De La Rosette JJ, Schalken JA, Kiemeney LA. Polymorphisms in the alpha1A-adrenoceptor gene do not modify the short- and long-term efficacy of alpha1-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia. BJU Int. 2006 Apr;97(4):852-5. Pubmed-link

van der Graaf CA, Netea MG, Franke B, Girardin SE, van der Meer JW, Kullberg BJ. Nucleotide oligomerization domain 2 (Nod2) is not involved in the pattern recognition of Candida albicans. Clin Vaccine Immunol. 2006 Mar;13(3):423-5. Pubmed-link

Radstake TR, Sweep FC, Welsing P, Franke B, Vermeulen SH, Geurts-Moespot A, Calandra T, Donn R, van Riel PL. Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor. Arthritis Rheum. 2005 Oct;52(10):3020-9. Pubmed-link

M.G. Netea, B.J. Kullberg, D. de Jong, B. Franke, T. Sprong, T. Naber, J.P.H. Drenth, J.W.M. van der Meer. NOD2 mediates antiinflammatory signals induced by TLR2 ligands: implications for Crohn's disease. Eur. J. Immunol. 2004, 34(7):2052-2059. Pubmed-link

Radstake TR, Franke B, Hanssen S, Netea MG, Welsing P, Barrera P, Joosten LA, van Riel PL, van den Berg WB. The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. Arthritis Rheum. 2004; 50(3):999-1001. Pubmed-link

de Jong DJ, Franke B, Naber AH, Willemen JJ, Heister AJ, Brunner HG, Kovel CG, Hol FA. No evidence for involvement of IL-4R and CD11B from the IBD1 region and STAT6 in the IBD2 region in Crohn's disease Eur J Hum Genet 2003; 11(11):884-887 Pubmed-link

Neural tube defects

van der Linden IJ, Nguyen U, Heil SG, Franke B, Vloet S, Gellekink H, den Heijer M, Blom HJ. Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida. Mol Genet Metab. 2007 May;91(1):98-103. Epub 2007 Mar 2. Pubmed-link

Klootwijk R, Schijvenaars MM, Mariman EC, Franke B. Further characterization of the genetic defect of the Bent tail mouse, a mouse model for human neural tube defects. Birth Defects Res A Clin Mol Teratol. 2004 Nov;70(11):880-4. Pubmed-link

Aruga J, Ogura H, Shutoh F, Ogawa M, Franke B, Nagao S, Mikoshiba K. Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent tail) mutant mice. Eur J Neurosci. 2004 Oct;20(8):2159-67. Pubmed-link

Groenen PM, Klootwijk R, Schijvenaars MM, Straatman H, Mariman EC, Franke B, Steegers-Theunissen RP. Spina bifida and genetic factors related to myo-inositol, glucose, and zinc. Mol Genet Metab. 2004 Jun;82(2):154-61. Pubmed-link

Franke B, Klootwijk R, Lemmers B, de Kovel CG, Steegers-Theunissen RP, Mariman EC. Phenotype of the neural tube defect mouse model bent tail is not sensitive to maternal folinic acid, myo-inositol, or zinc supplementation. Birth Defects Res A Clin Mol Teratol. 2003 Dec;67(12):979-84. Pubmed-link

Groenen PM, Peer PG, Wevers RA, Swinkels DW, Franke B, Mariman EC, Steegers-Theunissen RP. Maternal myo-inositol, glucose, and zinc status is associated with the risk of offspring with spina bifida. Am J Obstet Gynecol. 2003; 189(6):1713-9. Pubmed-link

Klootwijk R, Groenen P, Schijvenaars M, Hol F, Hamel B, Straatman H, Steegers-Theunissen R, Mariman E, Franke B. Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans. Am. J. of Med. Genetics. (2004); 124A(1), : 40-47 Pubmed-link

Klootwijk R, Hol FA, Wu M, Willemen JJ, Groenen P, Hamel B, Straatman H, Steegers-Theunissen RP, Mariman EC, Franke B. Genetic variation analysis of MLP, TFAP2A, and CSK in patients with neural tube defects. J Med Genet 2003; 40(4):E43. Pubmed-link

Franke B, Klootwijk R, Hekking JW, De Boer RT, Ten Donkelaar HJ, Mariman EC, Van Straaten HW.. Analysis of the embryonic phenotype of Bent tail, a mouse model for X-linked neural tube defects. Anat Embryol(Berl) 2003; 207: 255-262 Pubmed-link

Klootwijk R, Franke B, van der Zee CE, de Boer RT, Wilms W, Hol FA, Mariman EC. (2000) A deletion encompassing Zic3 in bent tail, a mouse model for X-linked neural tube defects. Hum Mol Genet 2000; 9(11):1615-22 Pubmed-link

Other

De Kovel, C.G.F. 2003. Dyslexie: genetische aspecten. In: Peters, H.F.M., Bastiaanse, R., van Borsel, J., Dejonckere, P.H.O., Jansonius-Schultheiss, K., Van der Meulen, Sj., Mondelaers, B.J.E. (eds) Handboek Stem- Spraak- en Taalpathologie Vol.20, Bohn Stafleu van Loghum, Houten. manuscript